Prednisolone: Steroid to Treat Allergies and Infections
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Prednisolone is in a class of medications called steroids. It can treat many diseases and conditions, especially those related to inflammation.
What is Prednisolone acetate used for?
Prednisolone acetate is used for the treatment of adrenal cortex insufficiency, congenital adrenal hyperplasia, subacute thyroiditis, contact dermatitis, serum sickness, persistent or seasonal allergic rhinitis, angioedema, rheumatoid arthritis, ankylosing systemic spondylitis, periarteritis nodosa, recurrent polychondritis, systemic vasculitis, exfoliative dermatitis, severe seborrheic dermatitis, pemphigus, severe psoriasis. It is also used to help reduce the symptoms of asthma, such as wheeze.
Its use is advisable in the treatment of autoimmune diseases, inflammatory lesions of the joints, eye diseases, lesions of the respiratory and liver organs, as well as cardiovascular, neurological and oncological diseases.
The medicine is often used in transplantology to prevent a rejection reaction.
Why does Prednisolone make you feel good?
This drug belongs to the group of antimicrobial and antiseptic substances, based on corticosteroid components intended for systemic use.
Prednisolone is a synthetic corticosteroid used to reduce inflammatory processes since it has the property of inhibiting the secretion and release of inflammatory mediators.
The drug inhibits the accumulation of cells (leukocytes, macrophages, etc.) in the inflamed area and helps reduce capillary permeability.
It has an immunosuppressive effect, has an effect on the balance of electrolytes, helping to enhance the reabsorption of water and sodium, increasing the release of sodium molecules and hydrogen ions.
It helps restore adrenal function, increases protein catabolism, the content of glucose and lipid acids in the blood, affects the metabolism of amino acids.
The drug also reduces the likelihood of scar tissue formation.
What is the difference between Prednisone and Prednisolone?
Prednisolone and prednisone are both synthetic man-made glucocorticoids used to treat various disorders associated with inflammatory and autoimmune processes. Prednisolone is the active metabolite of prednisone. Prednisone is processed in the liver to prednisolone which then crosses the cellular membrane.
Dosing schedules for prednisone and prednisolone are usually similar and range from 5mg to 60mg per day.
The drugs have similar indications, the same side effects and interactions.
How quickly does Prednisolone work?
The drug works very quickly — usually within one to four days provided that the dose you are taking is chosen correctly and is able to reduce your inflammation. Some patients notice the improvement several hours after taking the first dose.
Is Prednisolone a painkiller?
This medicine has been shown to reduce spontaneous discharge in an injured nerve, which reduces neuropathic pain. So prednisone or prednisolone can also be used to relieve pain.
How to take this medicine?
The tablets are taken orally without chewing. In each specific case, the dose of the drug is selected individually. When choosing a dose, the circadian rhythm of glucocorticoid secretion in the body must be taken into account, in this regard, 2/3 of the daily dose or the entire dose is recommended to be taken in the morning (8 am) and 1/3 of the dose in the evening. When the drug is withdrawn, the dosage is gradually reduced until it is completely discontinued.
Prednisolone dose for allergic reaction is 20 mg to 30 mg, daily maintenance dose is 5 mg to 10 mg. If necessary, the initial daily dose can be 15 to 100 mg.
Prednisolone for kids: 1 or 2 mg per kg of body weight, and the maintenance dose for children is 300 to 600 μg per kg of body weight. The daily dose for the treatment of children should be divided into 4 or 6 doses.
What are the contraindications for use?
Prednisolone is not prescribed if the patient has gastric or duodenal ulcers, renal failure, osteoporosis, a predisposition to thromboembolism, severe hypertension, herpes zoster, chickenpox and Cushing’s syndrome.
Can Prednisolone cause side effects?
Usually, the drug is well tolerated. Side effects can occur only with prolonged use of the drug.
In this case, patients may experience:
- convulsions, increased intracranial pressure;
- Cushing’s syndrome, growth suppression in children, menstrual irregularities, hyperglycemia, glucosuria, decreased carbohydrate tolerance;
- cataract, glaucoma, exophthalmos;
- leukocytosis;
- thrombosis;
- anaphylactic reactions, hypersensitivity reactions, obliterating arteritis, weight gain, fainting.
Use during pregnancy and breastfeeding
Prednisolone can be used in the treatment of pregnant women but only on strict medical grounds and under medical supervision.
When using the drug in the treatment of women at the lactation stage, it is necessary to make sure that the baby does not suffer from hyperbilirubinemia.
Can I overdose on this medicine?
The risk of overdose with Prednisolone increases significantly with prolonged use of the drug in high doses. In case of an overdose in patients, there is an increase in blood pressure, peripheral edema and an increase in side effects.
To stabilize the condition, it is recommended to temporarily stop taking the drug and adjust the dosage.
Interactions with other drugs
Avoid using Prednisolone with any of the following drugs:
- salicylates;
- diuretics;
- hypoglycemic drugs;
- cardiac glycosides;
- rifampicin;
- antihypertensive drugs;
- coumarin derivatives;
- phenytoin;
- barbiturates;
- hormonal contraceptives;
- acetylsalicylic acid;
- antipsychotics;
- carbutamide;
- azathioprine;
- m-anticholinergics (including antihistamines, tricyclic antidepressants);
- nitrates.
Prednisolone for dogs
Prednisolone can be used to treat dogs only after consulting a veterinarian since the drug is hormonal, requires strict adherence to the dosage and is not suitable for self-medication.
The doctor prescribes a medicine based on examination data, analyzes.
Prednisolone is prescribed to dogs for the treatment of various pathologies: allergic dermatitis, hives, Quincke’s edema, toxicoderma, arthritis, arthrosis, synovitis, bursitis, other inflammatory processes in the joints, lupus erythematosus, autoimmune diseases of various types, leukemia, eczema and other skin pathologies, rheumatism, etc.
Also, the drug is used to treat Crohn’s disease, which is characterized by a lack of hormone production by the adrenal cortex. Often this medicine is used to prevent inflammation and edema after surgery. The medicine can be used to treat serious injuries, for example, when the dog is hit by a car. Sometimes it is used for colitis, kidney and liver diseases.
The dosage depends on the weight of the animal: usually, it is 1 mg per 1 kg of the dog’s weight.
Your dog needs to receive the medicine for 2 weeks twice a day. If there is an improvement, the dose is gradually reduced. You cannot abruptly cancel the medicine! You cannot change or reduce the dosage without consulting a veterinarian.
Important! This hormonal drug is contraindicated for use in pregnant and lactating females. The doctor should assess the risk to the dog and its offspring.
The drug is not prescribed to puppies during the growth period – it enhances the leaching of calcium from the body and disrupts the formation of the bone skeleton.
Where can I buy Prednisolone?
Today you can buy Prednisolone online at a low cost without any problems. Many manufacturers offer their products exclusively online. Finding this medicine at a city pharmacy can be problematic.
If you place an order online at United Way Pharmacy, the medicine will be delivered to the address indicated by the client. The product catalog allows the buyer to choose and order steroids in the right dosage and in the right quantity. Buying meds online, you save time and efforts. If you have any questions related to the selection or ordering of medicines will be answered by our support managers.
Reviews
According to user reviews, the use of Prednisolone helps eliminate unpleasant symptoms of many diseases. Doctors prescribe medication for the complex treatment of inflammatory and autoimmune processes. The drug quickly causes positive dynamics and has a beneficial effect on the patient’s condition. The medicine is able to interrupt the pathogenesis of the disease and significantly speed up recovery.